Rules
Not really rules, per se, but generally good things to keep in mind.
1) Think locally. If the answer to a clue is McDonald's and there's one across the street or one three towns over, check the one across the street first. For the most part the answer to clues will not be so generic as McDonald's. Keep in mind that a race will have boundries spelled out at the starting line, be it a county, or in the case of the Manhattan 2025 race an upper and lower street (likely the entire width of the island will be fair game).
2) Do not draw undue attention to a clue location to make it harder for another team to get the same opportunity you have. For the most part the locations of the race (and certainly not their neighbors!) will have no idea they are actually part of the race and likely will be unable to help you. Likewise, you should not employ them or any other people to "play defense" at a location for the next team(s) that arrive.
3) If the Race Master can't do it they wouldn't expect you to do it. The Race Master won't ask you to swim the East River, and they will not put a clue on the outside of the observation deck of the Empire State Building. Before you go running into the polar bear exhibit at the Central Park Zoo, ask yourself, "is this something the Race Master would do?" Probably equally qualifed by "is this something the Race Master would have gotten away with doing?" as the Race Master personally travels the entire race before the start to make sure it works.
4) At the starting line you'll be told the time the race will end. At this time all teams must call the Race Master and can ask for the finish line. The winner will be determined by whoever got the furthest (if no other teams have finished by this point). Of course your team can feel free to continue on until you reach the end naturally, but you will need to call in at this time.
5) At least one member of your team will be likely required to have a camera phone and a data plan capable of sending pictures. Feel free to take more pictures along the way for use on the next update of the website. (This requirement is still in flux, but who doesn't have this anyway?)
6) Most importantly, have fun. It's what this is all about.